Polynucleotide (PDRN) Injections
The Regeneration Revolution in Dermatology
What Are Polynucleotides (PN) and PDRN?
Let’s break it down.
Polynucleotides (PN) are fragments of DNA extracted from salmon or trout sperm cells — yes, really! Don’t let that scare you; these molecules are biocompatible and highly purified for safe medical use.
PDRN (Polydeoxyribonucleotide) is a specific type of polynucleotide that has shown remarkable regenerative properties when injected into the skin.
In simpler terms, PN/PDRN injections are like giving your skin a biological wake-up call — they stimulate cellular repair, boost fibroblast activity, and enhance tissue regeneration.
What Makes Polynucleotide Injections Special?
Wound Healing + Skin Repair
PDRN binds to specific receptors in your skin, triggering tissue repair, angiogenesis (new blood vessel formation), and collagen remodeling.
Anti-Inflammatory Action
It reduces inflammation by modulating cytokine activity, making it perfect for sensitive or post-procedure skin.
Skin Quality Transformation
Patients report improved texture, hydration, elasticity, and overall glow after treatments.
Safe for Sensitive Skin
Unlike fillers or aggressive treatments, PN injections are gentle yet powerful — suitable even for rosacea-prone or post-laser skin.
What Can Polynucleotide Injections Treat?
• Fine lines and wrinkles
• Acne scars
• Under-eye dark circles and hollows
• Skin laxity on face and neck
• Stretch marks
• Hair loss (as part of scalp therapy)
• Post-laser or post-needling recovery
Treatment Protocol
Typically, we recommend:
3–4 sessions spaced 2–4 weeks apart
Maintenance session every 6–12 months
Treatment is performed with microinjections or mesotherapy guns, delivering the polynucleotide solution into the superficial dermis.
| Feature | Polynucleotide Injections | Dermal Fillers | Skin Boosters |
|---|---|---|---|
| Main purpose | Regeneration, repair, healing | Add volume, reshape | Hydration, soft tissue glow |
| Composition | DNA fragments (salmon source) | Hyaluronic acid (cross-linked) | Hyaluronic acid (non-cross-linked) |
| Skin effect | Boosts collagen, repairs damage | Restores facial volume | Moisturizes and smoothens skin |
| Ideal for | Thin, crepey, sensitive skin | Cheeks, lips, chin, nose | Fine lines, overall hydration |
Why Are Dermatologists Excited About PN/PDRN?
Because it’s biological rejuvenation — not mechanical filling or synthetic boosting. PN and PDRN work with your own skin’s regenerative abilities, making them a natural anti-aging powerhouse.
Polynucleotide Injections in 2025: Trending Uses
Periorbital rejuvenation (under-eye area) → Reduces crepey texture, puffiness, and dark circles
Scalp microinjections for hair loss → Improves scalp health, complements PRP or exosomes
Post-procedure skin recovery → Speeds up healing after lasers, microneedling, or peels
Stretch marks and body scars → Improves skin elasticity and appearance
Dermosphere’s Expert Recommendations
At Dermosphere Clinic, we personalize PN/PDRN treatments:
Combine with microneedling or MNRF for acne scar repair
Use alongside PRP or exosome therapy for hair regrowth
Pair with bio-remodelling injections (like Profhilo) for full-face rejuvenation
Follow with a medical-grade skincare routine to maintain results
Are There Side Effects?
Mild redness or swelling for 1–2 days
Occasional bruising at injection sites
Rare allergic reactions (very rare, due to biocompatibility)
We always perform a thorough consultation before treatment to ensure safety and suitability.
Patient Reviews
“I’ve tried fillers before, but PDRN gave me a natural glow and smoothness I didn’t expect.”
“Perfect treatment after my CO₂ laser — my skin healed faster and looked amazing.”
“My under-eye area looks fresher and less tired without adding volume — I love it!”
Global Brands to Know
Popular PN/PDRN brands include:
• Rejuran Healer (South Korea)
• Plinest (Italy)
• PhilArt (Croma Pharma, Europe)
At Dermosphere, we only use clinically proven, authentic products.